Chemical Communications

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

Q Cai, Z Li, J Wei, C Ha, D Pei, K Ding

文献索引：Cai, Qian; Li, Zhengqiu; Wei, Jiajia; Ha, Chengyong; Pei, Duanqing; Ding, Ke Chemical Communications, 2009 , # 48 p. 7581 - 7583

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被引用次数: 28

摘要

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand- free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-subtrates under room temperature or mild conditions.