Synthesis

[bmim] Br3 as a new reagent for regioselective monobromination of arylamines under solvent-free conditions

ZG Le, ZC Chen, Y Hu, QG Zheng

文献索引：Le, Zhang-Gao; Chen, Zhen-Chu; Hu, Yi; Zheng, Qin-Guo Synthesis, 2004 , # 17 p. 2809 - 2812

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被引用次数: 15

摘要

1-Butyl-3-methylimidazolium tribromide ([bmim]Br 3 ), is an efficient and novel reagent for the regioselective monobromination of arylamines. We found that the reaction of aniline (1a) with [bmim]Br 3 (Scheme [1] ), occurred rapidly under solvent-free conditions at -10 °C and was complete within two minutes. The reaction leads to selective monobromination, preferentially in the para position (Table [1] , entry 1), to produce p-bromoaniline (2a). In similar fashion, the ...