The Journal of organic chemistry

Combined Directed Remote Metalation− Transition Metal Catalyzed Cross Coupling Strategies: The Total Synthesis of the Aglycones of the Gilvocarcins V, M, and E …

CA James, V Snieckus

文献索引：James, Clint A.; Snieckus, Victor Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4080 - 4093

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被引用次数: 69

摘要

A key directed remote metalation (DreM)− carbamoyl migration strategy was applied in an efficient synthesis of the naturally occurring 6H-naphtho [1, 2-b] benzopyran-6-one defucogilvocarcin V (1a, Scheme 11). The required biarylcarbamate 33d was best prepared by a high yielding Suzuki coupling reaction of 31a with the differentially protected trioxygenated naphthalene coupling partner 32d which was synthesized using a selective ...