Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides

…, RU Ostrovskaya, GG Rozantsev, NI Vasilevich…

文献索引：Gudasheva; Voronina; Ostrovskaya; Rozantsev; Vasilevich; Trofimov; Kravchenko; Skoldinov; Seredenin European Journal of Medicinal Chemistry, 1996 , vol. 31, # 2 p. 151 - 157

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被引用次数: 91

摘要

Esters and amides of a series of N-acylprolyl-containing dipeptides were synthesized. It was established that these substances possess the ability to prevent memory decline evoked by maximal electroshock (MES) in a passive avoidance step-through paradigm. These N- acylprolyl-containing dipeptides were designed as analogues of pyroglutamyl-containing dipeptides, which we previously demonstrated to be highly active nootropics. Among the ...