Il Farmaco

4-Substituted 1, 5-diarylpyrazole, analogues of celecoxib: synthesis and preliminary evaluation of biological properties

G Menozzi, L Merello, P Fossa, L Mosti, A Piana…

文献索引：Menozzi, Giulia; Merello, Luisa; Fossa, Paola; Mosti, Luisa; Piana, Antonietta; Mattioli, Francesca Farmaco, 2003 , vol. 58, # 9 p. 795 - 808

全文：HTML全文

被引用次数: 24

摘要

A number of 5-aryl-1-[4-(methylsulfonyl)-phenyl]-1H-pyrazoles and 4-(5-aryl-1H-pyrazol-1- yl) benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib (celebrex), were synthesized. In order to verify the effects on the biological properties of certain substituents put on position 4 of the pyrazole nucleus, some of these compounds were screened in vivo for their anti-inflammatory and analgesic activities. Moreover, ...