Synthesis and DNA cleavage studies of novel quinoline oxime esters

PJ Bindu, KM Mahadevan, ND Satyanarayan…

文献索引：Bindu; Mahadevan; Satyanarayan; Ravikumar Naik Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 898 - 900

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被引用次数: 36

摘要

New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3- formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0° C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline ...