Synthesis and DNA cleavage studies of novel quinoline oxime esters

PJ Bindu, KM Mahadevan, ND Satyanarayan…

Index: Bindu; Mahadevan; Satyanarayan; Ravikumar Naik Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 898 - 900

Full Text: HTML

Citation Number: 36

Abstract

New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3- formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0° C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline ...