Tetrahedron

Mild and efficient barbier allylation reaction mediated by magnesium powder under solvent-free conditions

S Li, JX Wang, X Wen, X Ma

文献索引：Li, Shunxi; Wang, Jin-Xian; Wen, Xiaoliu; Ma, Xiaofang Tetrahedron, 2011 , vol. 67, # 5 p. 849 - 855

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被引用次数: 36

摘要

A novel and highly efficient synthesis of homoallylic alcohols is achieved by the allylation of carbonyl compounds using magnesium powder as mediator under solvent-free conditions. A series of aldehydes and ketones are converted to the corresponding homoallylic alcohols, the yields of the reaction is considerably high (85–98%). The procedure is environment benign, operationally simple and easy to scale up at room temperature.