Irreversible and highly enantioselective acylation of 2-halo-1-arylethanols in organic solvents catalyzed by a lipase from Pseudomonas fluorescens

J Hiratake, M Inagaki, T Nishioka…

文献索引：Hiratake, Jun; Inagaki, Minoru; Nishioka, Takaaki; Oda, Jun'ichi Journal of Organic Chemistry, 1988 , vol. 53, # 26 p. 6130 - 6133

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被引用次数: 88

摘要

Figure 1. Lipase-catalyzed transesterification of 1-hexanol with vinyl acetate (O), isopropenyl acetate (O), vinyl butyrate (A), vinyl octanoate (w), 2, 2, 2-trichloroethyl acetate (A), and ethyl acetate (0). Conditions: 1-hexanol (10 mmol), enol esters 1 (10.5 mmol), lipase Amano P (500 mg), dry diisopropyl ether (20 mL), 25" C. Detection: GC (2% XE-60, 2 m, 70" C, ethyl benzene as internal standard).