Archiv der Pharmazie

Total Synthesis and Further Scrutiny of the in vitro Antifungal Activity of 6??Nonadecynoic Acid

NM Carballeira, D Sanabria, K Parang

文献索引：Carballeira, Nestor M.; Sanabria, David; Parang, Keykavous Archiv der Pharmazie, 2005 , vol. 338, # 9 p. 441 - 443

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被引用次数: 9

摘要

Abstract The antifungal, naturally occurring acetylenic fatty acid 6-nonadecynoic acid was synthesized in three steps (18% overall yield), for the first time starting with commercially available 1-tetradecyne. The synthesis developed herein will facilitate the further study of the antifungal properties of this naturally occurring acetylenic fatty acid. The 6-nonadecynoic acid exhibited the best antifungal activity (< 4.3 μM) against Cryptococcus neoformans ...