Abstract The antifungal, naturally occurring acetylenic fatty acid 6-nonadecynoic acid was synthesized in three steps (18% overall yield), for the first time starting with commercially available 1-tetradecyne. The synthesis developed herein will facilitate the further study of the antifungal properties of this naturally occurring acetylenic fatty acid. The 6-nonadecynoic acid exhibited the best antifungal activity (< 4.3 μM) against Cryptococcus neoformans ...
![1-[(tetrahydropyran-2-yl)oxy]-6-nonadecyne Structure](https://image.chemsrc.com/caspic/492/878477-15-7.png)
