The Journal of Organic Chemistry

Asymmetric reduction of nitro olefins by fermenting bakers' yeast

H Ohta, N Kobayashi, K Ozaki

文献索引：Ohta, Hiromichi; Kobayashi, Naoki; Ozaki, Kazuhiko Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1802 - 1804

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被引用次数: 97

摘要

Reduction of a number of 1-nitro-1-alkenes by fermenting bakers' yeast has been found to be enantioselective, resulting in the formation of optically active 1-nitroalkanes. In most cases, optical purities of the products determined by HPLC analysis of MTPA amides were as high as 83-98% ee. The optimum rate of conversion was obtained when the reaction was carried out at pH 8 and low concentration of substrates. The absolute configuration of ...