Enantiomerically pure nitroalkanes are valuable intermediates in organic synthesis. They can be easily converted to other versatile building blocks, such as amines, aldehydes, carboxylic acids, nitrile oxides, and denitrated compounds.[1] Structural motifs derived from chiral β-branched nitroalkanes can be found in many small molecule pharmaceuticals, such as catramilast, for the treatment of atopic dermatitis, the muscle relaxant baclofen,[2] and ...
