前往化源商城

European journal of medicinal chemistry

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

KF Ansari, C Lal

文献索引:Ansari; Lal European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4028 - 4033

全文:HTML全文

被引用次数: 166

摘要

Some derivatives of benzimidazole were synthesized by nucleophilic substitution of 2- substituted-1H-benzimidazole. The resulting ethyl (2-substituted-1H-benzimidazol-1-yl) acetate on treatment with hydrazine hydrate yielded 2-(2-substituted-1H-benzimidazol-1-yl) acetohydrazide, which on further reaction with one equivalent of different aliphatic or aromatic carboxylic acids in the presence of phosphoryl chloride afforded the ...