4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators

JJP Zhou, J Li, S Upadhyaya, PE Eaton…

文献索引：Eaton; Nodari; Tsanaktsidis; Upadhyaya Synthesis, 1995 , # 5 p. 501 - 502

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被引用次数: 19

摘要

Cubylcarbinylamine (1a),(4-cyclopropylcubyl) carbinylamine (1b), and (4-phenylcubyl) carbinylamine (1c) were synthesized and shown to be time-dependent, irreversible inactivators of monoamine oxidase B (MAO B). Substrate protects the enzyme from