Targeting ACE and ECE with dual acting inhibitors

…, A Benoist, P Mennecier, A Rupin, TJ Verbeuren…

文献索引：Hanessian, Stephen; Guesne, Sebastien; Riber, Ludivine; Marin, Julien; Benoist, Alain; Mennecier, Philippe; Rupin, Alain; Verbeuren, Tony J.; Nanteuil, Guillaume De Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1058 - 1062

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被引用次数: 4

摘要

A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.