A phosphonamidate dipeptide analog as an inhibitor of carboxypeptidase A

NE Jacobsen, PA Bartlett

文献索引：Jacobsen,N.E.; Bartlett,P.A. Journal of the American Chemical Society, 1981 , vol. 103, p. 654

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被引用次数: 218

摘要

Abstract: The application of a new strategy for the design of potential transition-state analogues for carboxypeptidase A (CPA) has led to the development of a potent competitive inhibitor. N-[[[(Benzyloxycarbonyl) amino] methyl] hydroxy-phosphinyll-L-phenylalanine, dilithium salt,(ZG” P), 4, is an analogue of the substrate Z-Gly-L-Phe with a tetrahedral phosphonamidate moiety in place of the scissile peptide group. ZG” P is a competitive, ...