A synthetic route has been developed to the synthesis of a chiral O-alkyloxime (S)-16, which can be a synthetic intermediate for a potent antipsedomonal cephalosporin antibiotic M- 14659 (1). The oxime moiety in (S)-16 has a chiral center at the carbon atom adjacent to the oxygen atom. We have achieved that (S)-16 can be prepared via t-butyl 2-aminooxy-2-[3, 4- (isopropylidenedioxy) phenyl] acetate [(S)-15] from an optically active α-(phthalimidooxy) ...
