Model studies support pyrrolylation of the topaquinone cofactor to explain inactivation of bovine plasma amine oxidase by 3-pyrrolines. Unusual processing of a …

Y Lee, H Huang, LM Sayre

文献索引：Lee, Younghee; Huang, He; Sayre, Lawrence M. Journal of the American Chemical Society, 1996 , vol. 118, # 30 p. 7241 - 7242

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被引用次数: 32

摘要

Since the report in 1990 that the active carbonyl cofactor used by plasma and other copper amine oxidases is the quinone form (topaquinone, TPQ) of an active site 2, 4, 5- trihydroxyphenylalanine residue, 1 there has been renewed interest in mechanistic and directed model studies. 2-7 A pyridoxal-like transamination mechanism appears to be in force for the enzyme (Scheme 1, path A), since anaerobic single turnover results in ...