3-Pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases

…, RB Silverman, EM Shepard, DM Dooley…

文献索引：Lee, Younghee; Ling, Ke-Qing; Lu, Xingliang; Silverman, Richard B.; Shepard; Dooley; Sayre, Lawrence M. Journal of the American Chemical Society, 2002 , vol. 124, # 41 p. 12135 - 12143

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被引用次数: 60

摘要

We previously reported that 3-pyrroline and 3-phenyl-3-pyrroline effect a time-dependent inactivation of the copper-containing quinone-dependent amine oxidase from bovine plasma (BPAO)(Lee et al. J. Am. Chem. Soc. 1996, 118, 7241-7242). Quinone cofactor model studies suggested a mechanism involving stoichiometric turnover to a stable pyrrolylated cofactor. Full details of the model studies are now reported along with data on ...