Synthesis, structure–activity relationship of novel substituted 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer …

…, P Suman, P Yogeeswari, D Sriram, TB Shaik…

文献索引：China Raju; Nageswara Rao; Suman; Yogeeswari; Sriram; Shaik, Thokhir Basha; Kalivendi, Shasi Vardhan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2855 - 2859

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被引用次数: 60

摘要

Abstract Series of 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives 7a– 7zb, 8a–8d and 9a–9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H 37 Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that six compounds are more potent and 7za is most effective anti-mycobacterial derivative ...