Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells

…, S Chesnov, A Guggisberg, K Popaj…

文献索引：Popaj, Kasim; Hesse, Manfred Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 180 - 186

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被引用次数: 38

摘要

In solid tumors, when O2 partial pressure drops below 10 mmHg, ATP levels rapidly decrease due to the Warburg effect. It is known that certain macrocyclic polyamines catalyze the chemical hydrolysis of ATP with release of inorganic phosphate. Since tumor cells have