Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells

…, S Chesnov, A Guggisberg, K Popaj…

Index: Popaj, Kasim; Hesse, Manfred Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 180 - 186

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Citation Number: 38

Abstract

In solid tumors, when O2 partial pressure drops below 10 mmHg, ATP levels rapidly decrease due to the Warburg effect. It is known that certain macrocyclic polyamines catalyze the chemical hydrolysis of ATP with release of inorganic phosphate. Since tumor cells have