Studies on the synthesis and biological properties of non-carrier-added [125I and 131I]-labeled arylalkylidenebisphosphonates: potent bone-seekers for diagnosis …

E Årstad, P Hoff, L Skattebøl, A Skretting…

文献索引：Arstad, Erik; Hoff, Per; Skattebol, Lars; Skretting, Arne; Breistol, Knut Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3021 - 3032

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被引用次数: 23

摘要

Arylalkylidenebisphosphonates labeled with nca [125I or 131I] have been synthesized and their biological function investigated. The label was attached to the aromatic group in high yield and under mild conditions by means of iododesilylation. The bone affinities of the radioactive compounds were investigated in normal Balb/C mice. The compound 1-hydroxy (m-iodo [125,131 I]-phenylethylidene)-1, 1-bisphosphonate was found to possess superior ...