Regioselective hydrolysis of diesters of (Z)-and (E)-2-methyl-butenedioic acids by PLE

…, V Partali, T Anthonsen, HW Anthonsen, L Kvittingen

文献索引：Schmid, Rudolf; Partali, Vassilia; Anthonsen, Thorleif; Anthonsen, Henrik W; Kvittingen, Lise Tetrahedron Letters, 2001 , vol. 42, # 48 p. 8543 - 8545

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被引用次数: 2

摘要

Dimethyl, diethyl and dipropyl esters of (Z)-and (E)-2-methyl-butenedioic acids (citraconic and mesaconic acid) were hydrolysed by pig live esterase, PLE. For the diethyl esters the enzyme showed low regioselectivity for both the (Z)-and the (E)-isomers. However, the hydrolysis of dimethyl and dipropyl (Z)-2-methyl-butenedioic acid gave a ratio of the monoesters of 95: 5 and 85: 15.