A ribozyme with michaelase activity: synthesis of the substrate precursors

…, G Sengle, LR Takaoka, JS Nowick, M Famulok

文献索引：Eisenfuehr, Alexander; Arora, Paramjit S; Sengle, Gerhard; Takaoka, Leo R; Nowick, James S; Famulok, Michael Bioorganic and medicinal chemistry, 2003 , vol. 11, # 2 p. 235 - 249

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被引用次数: 63

摘要

The ability to generate RNA molecules that can catalyze complex organic transformations not only facilitates the reconstruction and plausibility of possible prebiotic reaction pathways but is also crucial for elucidating the potential of the application of RNA catalysts in organic syntheses. Iterative RNA selection previously identified a ribozyme that catalyzes the Michael addition of a cysteine thiol to an α, β-unsaturated amide. This reaction is ...