Design, synthesis, and structure-activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA: cholesterol acyltransferase (ACAT) …

…, JT Billheimer, DA Cromley, S Germain…

文献索引：Maduskuie, Thomas P.; Wilde, Richard G.; Billheimer, Jeffrey T.; Cromley, Debra A.; Germain, Sandra; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 7 p. 1067 - 1083

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被引用次数: 28

摘要

Acyl-CoAcholesterol acyltransferase (ACAT) is the primary enzyme involved in intracellular cholesterol esterification. Arterial wall infiltration by macrophages and subsequent uncontrolled esterification of cholesterol leading to foam cell formation is believed to be an important process which leads to the development of fatty streaks. Inhibitors of the ACAT enzyme may retard this atherogenic process. We have recently discovered a series of imidazoles which are potent in vitro ...