Synthesis and anti-inflammatory activity of substituted 2-styryl-4-(δ-diethylamino-α-methylbutylamino)-6-nitro-and 2-styryl-4-(δ-diethylamino-α-methylbutylamino)-6- …

GP Zhikhareva, LI Mastafanova, MI Evstratova…

文献索引：Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Shvarts, G. Ya.; Syubaev, R. D.; et al. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 119 - 123 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 45 - 49

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摘要

The starting compounds for the synthesis of the substituted 2-styryl-4-(6-diethylaminoa- methylbutylamino)-6-nitro-(IV) and 2-styryl-4-(~-diethylamino-~-methylbutylamino)-6- aminoquinazolines (V) was 2-methyl-6-nitro-4-quinazolone (I), prepared by nitration of 2- methyl-4-quinazolone by the literature method [3] in 62% yield after recrystallization from 50% acetic acid oo]: OH (O~ i-~)(Cn:)~(OZHS): NO 2..~.. J<.. NO t~.. I. NO t~. J,."-Y~ IY~---- ...