Synthesis and chemotherapeutic studies of 2-styryl-4-(δ-diethylamino-α-methylbutylamino) quinazolines

GP Zhikhareva, LI Mastafanova, MI Evstratova…

文献索引：Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Polukhina, L. M.; Nikolaeva, I. S.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 2 p. 122 - 127 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 2 p. 183 - 188

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摘要

The compounds were synthesized by a previously developed general method [7, 8], from the appropriate 2-methyl-4-quinazolones (I), which were converted via the 2-methyl-4- chloroquinazolines (II) into the 2-methyl-4-(~-diethylamino-~-methylbutylamino) quianazolines (III), followed by condensation with substituted aldehydes to give the 2-styryl- 4-(~-diethylaminomethylbutylamino) quinazolines (IVa-o)(Table I) required for ...