Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells

…, M Ye, DJ Donnelly, TY Ohulchanskyy, Y You…

文献索引：Gibson, Scott L.; Holt, Jason J.; Ye, Mao; Donnelly, David J.; Ohulchanskyy, Tymish Y.; You, Youngjae; Detty, Michael R. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6394 - 6403

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被引用次数: 22

摘要

Several thio and seleno analogues of tetramethylrosamine (TMR) were prepared. Thio derivatives of TMR have absorption maxima near 570nm, while seleno derivatives of TMR have absorption maxima near 580nm. The 3-or 4-N, N-dimethylaminophenyl substituent in the 9-position greatly increases internal conversion, which lowers quantum yields for fluorescence and the generation of singlet oxygen. Thio and seleno analogues of TMR ...