Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells

…, M Ye, DJ Donnelly, TY Ohulchanskyy, Y You…

Index: Gibson, Scott L.; Holt, Jason J.; Ye, Mao; Donnelly, David J.; Ohulchanskyy, Tymish Y.; You, Youngjae; Detty, Michael R. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6394 - 6403

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Citation Number: 22

Abstract

Several thio and seleno analogues of tetramethylrosamine (TMR) were prepared. Thio derivatives of TMR have absorption maxima near 570nm, while seleno derivatives of TMR have absorption maxima near 580nm. The 3-or 4-N, N-dimethylaminophenyl substituent in the 9-position greatly increases internal conversion, which lowers quantum yields for fluorescence and the generation of singlet oxygen. Thio and seleno analogues of TMR ...