Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties

JP Gotteland, A Delhon, D Junquero, P Oms…

文献索引：Gotteland; Delhon; Junquero; Oms; Halazy Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 533 - 538

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被引用次数: 15

摘要

(Arylamino) methylsilane derivatives 3 have been prepared and identified as potent inhibitors of human LDL oxidation mediated by copper (II). Combination of this property with the structural requirement of squalene epoxidase inhibitors led to the design and synthesis of the (arylamino) methylsilane derivative 4 which was characterised as the first potent, orally active squalene epoxidase inhibitor with antioxidant properties.