Synthesis of rac-hippospongic acid A and revision of the structure

M Tokumasu, H Ando, Y Hiraga, S Kojima…

文献索引：Tokumasu, Munetaka; Ando, Hiroshi; Hiraga, Yoshikazu; Kojima, Satoshi; Ohkata, Katsuo Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 489 - 496

全文：HTML全文

被引用次数: 22

摘要

rac-Hippospongic acid A of the reported structure 1 and the revised structure 2 were synthesized. The synthetic strategy of these compounds consists of homologation of (2E, 6E, 10E)-geranylgeraniol and (2E, 6E)-farnesol, respectively, Wadsworth–Emmons reaction, and cyclization to form the tetrahydropyran ring bearing an α-methylene group on the carboxylic moiety. Spectral comparisons of the synthetic compounds 1, 2 and the natural ...