2, 3-Epoxy-10-aza-10, 11-dihydrosqualene, a high-energy intermediate analog inhibitor of 2, 3-oxidosqualene cyclase

M Ceruti, G Balliano, F Viola, G Grosa…

文献索引：Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Grosa, Giorgio; Rocco, Flavio; Cattel, Luigi Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3050 - 3058

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被引用次数: 48

摘要

N-methylamine,(2) 3-(diphenylphosphinoyl) propanal, and (3) S, &epoxy-&methylheptan-2- one. The final stages of the reconstruction of the 6E double bond were obtained by a Wittig- Homer reaction which was modified for poorly reactive systems." his compound was designed to mimic the C-8 carbonium ion formed during SO cyclization. Its inhibitory activity on various SO cyh was evaluated and compared with the 6 2 isomer which has an ...