New aromatic monoesters of α-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
…, AM Sokol, M Sieńczyk, M Radziszewicz…
文献索引：Grzywa, Renata; Sokol, Anna M.; Sienczyk, Marcin; Radziszewicz, Magdalena; Kosciolek, Beata; Carty, Michael P.; Oleksyszyn, Jozef Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 8 p. 2930 - 2936
A series of new aromatic monoesters of α-aminoaralkylphosphonic acids were synthesized by selective hydrolysis of corresponding aromatic diesters of α-aminoaralkylphosphonic acids. New potential inhibitors of aminopeptidase N/CD13, an enzyme important in tumour angiogenesis, were developed. Some derivatives of the homophenylalanine and norleucine related monoaryl phosphonates displayed higher inhibition potency than corresponding α ...
