Tetrahedron letters

On the viability of 5-endo-dig cyclisations of O-propargylic hydroxylamine derivatives, leading to 2, 5-dihydroisoxazoles (3-isoxazolines)

OF Foot, DW Knight, ACL Low, YF Li

文献索引：Foot, Oliver F.; Knight, David W.; Low, Ai Cheng Lilian; Li, YingFa Tetrahedron Letters, 2007 , vol. 48, # 4 p. 647 - 650

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被引用次数: 23

摘要

O-Propargylic hydroxylamines undergo smooth 5-endo-dig cyclisations upon exposure to 3equiv of molecular iodine to give respectable yields of the corresponding 4-iodo-2, 5- dihydroisoxazoles, which should find a number of applications as intermediates for syntheses amongst this useful class of heterocycles.