Alkylmetal asymmetric reduction. 14. Enantioselective reduction of ketones by chiral (2-methylbutyl) aluminum derivatives

G Giacomelli, L Lardicci, F Palla…

文献索引：Giacomelli, Giampaolo; Lardicci, Luciano; Palla, Fabio; Caporusso, Anna Maria Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1725 - 1728

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被引用次数: 8

摘要

The reaction of tris [(S)-2-methylbutyl] aluminum with some a-alkynyl ketones has been studied: the organoaluminum derivative rapidly reduces the ketones to afford optically active a-alkynyl carbinols, which can be recovered after hydrolytic workup. The stereochemical results obtained are discussed on the basis of previous reports on enantioselective reductions of ketones by an alkylaluminum dichloride derived from 0-pinene. In this ...