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Synthesis, antitumor activity, and electrochemical behavior of some piperazinyl amidrazones

RJ Abdel-Jalil, EQ El Momani, M Hamad…

文献索引:Abdel-Jalil, Raid Jamil; El Momani, Ehab Q.; Hamad, Muawiah; Voelter, Wolfgang; Mubarak, Mohammad S.; Smith, Bianna H.; Peters, Dennis G. Monatshefte fur Chemie, 2010 , vol. 141, # 2 p. 251 - 258

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被引用次数: 21

摘要

Abstract New piperazinyl amidrazones have been synthesized by direct interaction of the corresponding aryl hydrazones with the appropriate piperazine. On the basis of preliminary screening data for these new compounds, the antitumor activity of 1-(4-methylpiperazin-1-yl)- 1, 2-propandione 1-[2-(4-chlorophenyl) hydrazone] and 1-(4-ethylpiperazin-1-yl)-1, 2- propandione 1-[2-(4-chlorophenyl) hydrazone] was evaluated. Mean 50% growth ...