Synthesis

An efficient synthesis of difluoropropargyl bromides

B Xu, M Mae, JA Hong, Y Li, GB Hammond

文献索引：Xu, Bo; Mae, Masayuki; Hong, Jiyoung A.; Li, Youhua; Hammond, Gerald B. Synthesis, 2006 , # 5 p. 803 - 806

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被引用次数: 18

摘要

Abstract High yields of γ-alkyl,-silyl and-aryl-substituted difluoropropargyl bromides have been obtained by monitoring concentration and temperature in the reaction between CF 2 Br 2 and γ-substituted lithium acetylide. γ-Silyl substituents afforded the corresponding α, α, α- difluorobromopropargyl alcohols in good yields via cleavage of tetrabutylammonium fluoride in the presence of an aldehyde.