Abstract High yields of γ-alkyl,-silyl and-aryl-substituted difluoropropargyl bromides have been obtained by monitoring concentration and temperature in the reaction between CF 2 Br 2 and γ-substituted lithium acetylide. γ-Silyl substituents afforded the corresponding α, α, α- difluorobromopropargyl alcohols in good yields via cleavage of tetrabutylammonium fluoride in the presence of an aldehyde.
[Fox, Mark A.; Cameron, Audrey M.; Low, Paul J.; Paterson, Michael A.J.; Batsanov, Andrei S.; Goeta, Andres E.; Rankin, David W.H.; Robertson, Heather E.; Schirlin, Julien T. Dalton Transactions, 2006 , # 29 p. 3544 - 3560]
[Fox, Mark A.; Cameron, Audrey M.; Low, Paul J.; Paterson, Michael A.J.; Batsanov, Andrei S.; Goeta, Andres E.; Rankin, David W.H.; Robertson, Heather E.; Schirlin, Julien T. Dalton Transactions, 2006 , # 29 p. 3544 - 3560]
