Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

…, J Purnell, R Ratliff, K Sebastian, J Zultowsky…

文献索引：Paula, Stefan; Abell, Josh; Deye, Joel; Elam, Christopher; Lape, Michael; Purnell, Justin; Ratliff, Robert; Sebastian, Kelly; Zultowsky, Jodie; Kempton, Robert J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6613 - 6619

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被引用次数: 8

摘要

Analogues of the compound 2, 5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ ...