Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

…, J Purnell, R Ratliff, K Sebastian, J Zultowsky…

Index: Paula, Stefan; Abell, Josh; Deye, Joel; Elam, Christopher; Lape, Michael; Purnell, Justin; Ratliff, Robert; Sebastian, Kelly; Zultowsky, Jodie; Kempton, Robert J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6613 - 6619

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Citation Number: 8

Abstract

Analogues of the compound 2, 5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ ...