Novel bifunctional macrocyclic chelating agents appended with a pendant-type carboxymethylamino ligand and nitrobenzyl group and stability of the 88YIII complexes

…, K Watanabe, Y Kato, T Koike, E Kimura

文献索引：Takenouchi, Kazuya; Watanabe, Kenzo; Kato, Yoshinori; Koike, Tohru; Kimura, Eiichii Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1955 - 1958

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被引用次数: 36

摘要

The chelating agent must form a stable radiometal complex because any liberated radiometal may be taken up by normal tissue and may cause radiation damage to nontarget cells. Further, such a compound must have a reactive site (X) by which it can be chemically linked to the antibody protein. Thus, the chelating agent must be bifunctional. Bifunctionalized EDTA or diethylenetriaminepentaacetic acid (DTPA) have been widely ...