Novel bifunctional macrocyclic chelating agents appended with a pendant-type carboxymethylamino ligand and nitrobenzyl group and stability of the 88YIII complexes

…, K Watanabe, Y Kato, T Koike, E Kimura

Index: Takenouchi, Kazuya; Watanabe, Kenzo; Kato, Yoshinori; Koike, Tohru; Kimura, Eiichii Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1955 - 1958

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Citation Number: 36

Abstract

The chelating agent must form a stable radiometal complex because any liberated radiometal may be taken up by normal tissue and may cause radiation damage to nontarget cells. Further, such a compound must have a reactive site (X) by which it can be chemically linked to the antibody protein. Thus, the chelating agent must be bifunctional. Bifunctionalized EDTA or diethylenetriaminepentaacetic acid (DTPA) have been widely ...