C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature
BH Lipshutz, S Huang, WWY Leong…
文献索引：Lipshutz, Bruce H.; Huang, Shenlin; Leong, Wendy Wen Yi; Zhong, Guofu; Isley, Nicholas A. Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 19985 - 19988
Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu (I), Ag (I), and Au (III) leads to 1, 4-adducts in good isolated yields: no organometallic precursor need be formed.
