Nuclear factor-κB mediated inhibition of cytokine production by imidazoline scaffolds

…, CD Hupp, TL Friebe, S Hovde, AD Jones…

文献索引：Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Hupp, Christopher D.; Friebe, Timothy L.; Hovde, Stacy; Jones, A. Daniel; Dyer, Richard D.; Henry, R. William; Tepe, Jetze J. Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1302 - 1309

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被引用次数: 26

摘要

The mammalian nuclear transcription factor NF-κB is responsible for the transcription of multiple cytokines, including the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Elevated levels of pro-inflammatory cytokines play an important role in the pathogenesis of inflammatory disorders such as rheumatoid arthritis (RA). Inhibition of the pro-inflammatory transcription factor NF-κB has therefore been ...