Synthesis of 4 (3H)??quinazolinones from derivatives of methyl 2??isothiocyanatobenzoate

WD Dean, EP Papadopoulos

文献索引：Dean, William D.; Papadopoulos, Eleftherios P. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1117 - 1124

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被引用次数: 29

摘要

Abstract Ethyl N-(2-methoxycarbonylphenyl) thiocarbamate (2), N-(2-ethoxycarbonylphenyl)- 4-methoxythiobenz-amide (3b), and 2-(4-methoxyphenyl)-4H-3, 1-benzothiazin-4-one (4a), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2-substituted and 2, 4-disubstituted 4 (3H) quinazolinones, as well as some tricyclic and tetracyclic products.