Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position

…, J Asano, N Ando, H Uchiki, K Fukuchi, T Anraku

文献索引：Takano, Yasuo; Shiga, Futoshi; Asano, Jun; Ando, Naoki; Uchiki, Hideharu; Fukuchi, Kazunori; Anraku, Tsuyosi Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 20 p. 5841 - 5863

全文：HTML全文

被引用次数: 9

摘要

We describe the design, synthesis, and biological properties of a novel series of 7- substituted 6-nitro-3-oxoquinoxaline-2-carboxylic acids. After designing, studying the structure–activity relationships, and evaluating the properties of various compounds, we found that 7-heterocyclic-6-nitro-3-oxoquinoxaline-2-carboxylic acids that contain a substituted phenyl group linked through urethane at the 7 position possess good α-amino- ...