Facile synthesis and nitration of cis-syn-cis-2, 6-dioxodecahydro-1H, 5H-diimidazo [4, 5-b: 4', 5'-e] pyrazine

…, VT Ramakrishnan, JH Boyer, IJ Dagley…

文献索引：Vedachalam, Murugappa; Ramakrishnan, Vayalakkavoor T.; Boyer, Joseph H.; Dagley, Ian J.; Nelson, Keith A.; et al. Journal of Organic Chemistry, 1991 , vol. 56, # 10 p. 3413 - 3419

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被引用次数: 35

摘要

The title ring system was synthesized for the first time by acid-promoted condensation of ureas with 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine. Nitrosation and nitration of the polycycle occurs fit at the piperazine nitrogens. Succeseive further nitration leads to tetra-, penta-, and hexanitro derivatives. X-ray crystallographic analysis of the tetra-and hexanitm derivatives established the cis-syn-cis configuration and an all-axial conformation for this ...