Deglycobleomycin: total synthesis and oxygen transfer properties of an active bleomycin analog

Y Aoyagi, H Suguna, N Murugesan…

文献索引：Aoyagi; Suguna; Murugesan; et al. Journal of the American Chemical Society, 1982 , vol. 104, # 19 p. 5237 - 5239

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被引用次数: 31

摘要

Bleomycin is the generic name that has been given to a family of clinically useful antitumor The bleomycins are believed to mediate their therapeutic effect via oxidative degradation of DNA.'This transformation has been investigated intensively, in part because such studies may permit the design of structurally simpler congeners of bleomycin having analogous biological properties. Presently, we describe a practicable total synthesis of ...